Hypothesis- I think the common spacer mod- thinning the spacer or replacing the spacer with a couple of washers- still leaves a too lean midrange that we often compensate for by over-jetting the main and sometimes the pilot.
Background- I've been running a 55 pilot w/ bleed holes, 1 turn out, 2 washers and 155 main. It's has a nice,smooth acceleration. However, gas mileage stinks so I've been wondering if I'm running too rich across all jettings. Today, I put in the 145 main and went for a ride. I had a very significant flat spot in the midrange with power returning on the high end but not quite as much as with the 155 main. Then I removed one washer and went for a ride again. Still a midrange flat spot but not quite as bad. Put in the 152.5 main and the flat spot was reduced to a barely noticeable spot and high end performance improved. Installed the 155 again and midrange was restored with a nice linear acceleration but high end no better than with the 152.5 main. So I discovered that 2 washers, and to a lesser extent 1 washer, is too lean for good midrange and that the overly rich pilot and main jet was hiding this fact. Here's my thoughts:
This is what I feel is an illustration of ideal jetting. The jets are even and overlap evenly with no significant overly rich or lean spots.

In comparison, this is stock. The pilot jet (with the factory idle mixture screw setting) and needle spacer make for a too lean condition but the main jet really is not all that bad especially with the stock airbox and stock muffler or unmodded HD muffler.

Doing the idle mixture screw mod and thinning the spacer to 2-3 washers fattens up the idle and midrrange areas and improves performance.

Going to a 55 pilot jet fattens up the idle circuit even more. So does going to a larger main jet. The result is increased overlap on both ends and starts to compensate for midrange leanness of 2 washers.

Going up another on the main increases the overlap and reduces the gap between pilot and main providing even more compensation for lean midrange. Performance improves but at the expense of running overly rich in the pilot and main.

So I'm thinking the most ideal baseline carb setup is:
Pilot: 52.5 (2-3 turns out) with airbox
55 without bleed holes (1 turn out) with pod filter
Spacer: no spacer (regardless of intake)
Main: 145-152.5 (depending on intake and exhaust)
Just my thoughts on the issue.