On last years Texas run, I was going to ride all the way in one shot from Ft. Walton Beach, Fl to Kerrville, TX but since I was meeting up with MMR, I stopped outside of Lafeyette, La. overnight.
Of course it was raining like mad... but if it had of been good weather I could have kept going.
Stopping every 100 miles gives you stretching time, even though it adds time to your trip.
I imagine if I were to do it in one whole ride (815 miles- 11hrs 40min) it would take me a whole day to recoup

and maybe some adult liquid refreshment to ease the bones....
Realistically, I would like to try it (I just did a 14 hour straight run in my truck to Illinois), but I would most likely have to stop at about the 600 mile mark.